Successful treatment of super-refractory tonic status epilepticus with rufinamide: First clinical report

نویسندگان

  • A.G.B. Thompson
  • H. R. Cock
چکیده

Rufinamide (RUF) is a novel antiepileptic agent that has entered clinical use within the last 10 years, thought to act through modulation of sodium channel activity [1]. Based on evidence from several independent randomised controlled trials (RCTs), RUF is used as an adjunctive agent in the treatment of Lennox–Gastaut syndrome (LGS) [2]. LGS is an epileptic encephalopathy syndrome, typically with onset in childhood, characterised by the presence of multiple seizure types including tonic, atonic and atypical absence seizures, and electroencephalography (EEG) showing slow spike-waves during waking, and fast rhythmic activity during sleep, as well as psychomotor delay and personality disorders. In addition to its use in LGS, RUF has shown some efficacy in other refractory epilepsy syndromes in both children and adults [3], though retention rates appear highest in LGS [4]. We are not aware of any prior experience of the use of RUF in status epilepticus. Here we present a case in which RUF was used as an adjunctive agent to treat super-refractory tonic status epilepticus, in a young adult male with an unusual epilepsy syndrome sharing some features with LGS.

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عنوان ژورنال:
  • Seizure

دوره 39  شماره 

صفحات  -

تاریخ انتشار 2016